Koumine

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For Research Use Only.

Size	Price	Stock	Quantity
25 mg	$299	In stock

Category

Alkaloids

Cat.No.

NP0400

CAS

1358-76-5

Product Name

Koumine

Structure

Product Details

Description

Koumine has a significant analgesic effect in rodent behavioral models of inflammatory and neuropathic pain, and that the reduction in neuropathic pain may be associated with the upregulation of allopregnanolone in the spinal cord. Koumine has the potential to be a future breast cancer chemotherapeutic agent.

Synonyms

(3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan; 7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-

IUPAC Name

(1R,10R,12S,15S,16R,17S)-15-ethenyl-13-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.02,10.04,9.010,15.012,17]icosa-2,4,6,8-tetraene

Molecular Weight

306.4

Molecular Formula

C20H22N2O

Canonical SMILES

CN1CC2(C3CC4C5=NC6=CC=CC=C6C52CC1C3CO4)C=C

InChI

InChI=1S/C20H22N2O/c1-3-19-11-22(2)16-9-20(19)13-6-4-5-7-15(13)21-18(20)17-8-14(19)12(16)10-23-17/h3-7,12,14,16-17H,1,8-11H2,2H3/t12-,14+,16-,17+,19-,20+/m0/s1

InChIKey

VTLYEMHGPMGUOT-FXWNUWCSSA-N

Boiling Point

436.5±45.0°C (Predicted)

Melting Point

168°C

Purity

>98%

Density

1.42 g/cm3

Appearance

Powder

Application

Antineoplastic

Storage

2-8°C

Form

Powder

MDL

MFCD11111448

Packaging

25 mg

pKa

8.67±0.40(Predicted)

Uses

Koumine is known to attenuate the lipopolysaccharide-stimulated inflammation in RAW264.7 macrophages.

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