Koumine

Inquiry
For Research Use Only.
Category
Alkaloids
Cat.No.
NP0400
CAS
1358-76-5
Product Name
Koumine
Structure
Structure
Size Price Stock Quantity
25 mg $299 In stock

Product Details

Description
Koumine has a significant analgesic effect in rodent behavioral models of inflammatory and neuropathic pain, and that the reduction in neuropathic pain may be associated with the upregulation of allopregnanolone in the spinal cord. Koumine has the potential to be a future breast cancer chemotherapeutic agent.
Synonyms
(3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan; 7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-
IUPAC Name
(1R,10R,12S,15S,16R,17S)-15-ethenyl-13-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.02,10.04,9.010,15.012,17]icosa-2,4,6,8-tetraene
Molecular Weight
306.4
Molecular Formula
C20H22N2O
Canonical SMILES
CN1CC2(C3CC4C5=NC6=CC=CC=C6C52CC1C3CO4)C=C
InChI
InChI=1S/C20H22N2O/c1-3-19-11-22(2)16-9-20(19)13-6-4-5-7-15(13)21-18(20)17-8-14(19)12(16)10-23-17/h3-7,12,14,16-17H,1,8-11H2,2H3/t12-,14+,16-,17+,19-,20+/m0/s1
InChIKey
VTLYEMHGPMGUOT-FXWNUWCSSA-N
Boiling Point
436.5±45.0°C (Predicted)
Melting Point
168°C
Purity
>98%
Density
1.42 g/cm3
Appearance
Powder
Application
Antineoplastic
Storage
2-8°C
Form
Powder
MDL
MFCD11111448
Packaging
25 mg
pKa
8.67±0.40(Predicted)
Uses
Koumine is known to attenuate the lipopolysaccharide-stimulated inflammation in RAW264.7 macrophages.
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