Isovitexin

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For Research Use Only.

Size	Price	Stock	Quantity
100 mg	$298	In stock

Category

Flavonoids

Cat.No.

NP1807

CAS

38953-85-4

Product Name

Isovitexin

Structure

Product Details

Description

Isovitexin, a food phytochemical contained in dietary rice products, or as a natural plant flavonoid isolated from the seeds of Vitex trifolia L, suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages. Isovitexin exhibits anti-inflammatory and anti-oxidant activities on lipopolysaccharide-induced acute lung injury by inhibiting MAPK and NF-κB and activating HO-1/Nrf2 pathways. Isovitexin can inhibit xanthine oxidase with an IC50 value of 15.2 microM, and it may protect cells from oxidative stress.

Synonyms

Saponaretin; Homovitexin; (1S)-1,5-anhydro-1-[5,7-dihydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-6-yl]-D-glucitol; 4H-1-Benzopyran-4-one, 6-β-D-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-; 6-β-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Flavone, 6-β-D-glucopyranosyl-4',5,7-trihydroxy-; Homovitexin; 6-C-Glucosylapigenin; 6-C-β-D-Glucopyranosylapigenin; Apigenin 6-C-β-D-glucoside; Apigenin 6-C-β-glucopyranoside; Apigenin-6-C-glucoside; Apigenin-6-C-β-D-glucopyranoside; Avroside; Isoavroside; Isovitexin (C-6 isomer); Saponaretin

IUPAC Name

5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one

Molecular Weight

432.38

Molecular Formula

C21H20O10

Canonical SMILES

C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)C4C(C(C(C(O4)CO)O)O)O)O)O

InChI

InChI=1S/C21H20O10/c22-7-14-17(26)19(28)20(29)21(31-14)16-11(25)6-13-15(18(16)27)10(24)5-12(30-13)8-1-3-9(23)4-2-8/h1-6,14,17,19-23,25-29H,7H2/t14-,17-,19+,20-,21+/m1/s1

InChIKey

MYXNWGACZJSMBT-VJXVFPJBSA-N

Boiling Point

807.0±65.0°C (Predicted)

Melting Point

257-258°C

Purity

98%

Density

1.686±0.06 g/cm3

Solubility

Soluble in DMF, DMSO

Appearance

Yellow powder

Storage

Store at 2-8°C

BRN

66651

Color

Yellow

Form

Powder

HS Code

29329990

pKa

5.93±0.40(Predicted)

Uses

Isovitexin is known as a flavones, a class of flavonoids. Isovitexin have been studied for their antiradical activities in the process of metabolisms. Isovitexin have also been studied for beneficial
effcts against atherosclerosis, osteoporosis and certain cancers.

WGK Germany

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