Description
A nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively.
Synonyms
indomethacin;53-86-1;indometacin;Indocin;Indomethacine;Indometacine;Indocid;Reumacide;Indomethazine;Metindol;Artrinovo;Confortid;Idomethine;Indomecol;Indomethacinum;Metartril;Methazine;Artrivia;Dolovin;Imbrilon;Indacin;Indomed;Indomee;Indoptol;Infrocin;Metacen;Sadoreum;Amuno;Inacid;Tannex;Indo-rectolmin;Inteban sp;Artracin;Durametacin;Indoptic;Inflazon;Mikametan;Lausit;Mezolin;Mobilan;Indo-tablinen;Indo-Lemmon;Indometacinum;Indometacyna;Indometicina;Indocin Sr;Indometacina;Aconip;2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid;Indmethacine;Dolcidium;Elmetacin;Indomethine;Indorektal;Tivorbex;Catlep;Indoxen;Vonum;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-;Indo-phlogont;Chibro-amuno;Bonidon Gel;Dolcidium PL;Rheumacin LA;Osmosin;1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid;CCRIS 3502;HSDB 3101;Indometacine [INN-French];Indometacinum [INN-Latin];Indometacina [INN-Spanish];FLAM;Inteban;1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid;NCI-C56144;UNII-XXE1CET956;1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid;EINECS 200-186-5;XXE1CET956;MFCD00057095;Indometacin [INN];NSC-757061;1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid;BRN 0497341;USAN;Indomethacin (Indocid, Indocin);CHEBI:49662;CHEMBL6;NSC-77541;IMN;Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-;Indomethacin [USAN:USP];alpha-(1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl)acetic acid;2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1h-indol-3-yl}acetic acid;N-p-Chlorbenzoyl-5-methoxy-2-methylindole-3-acetic acid;MLS000069402;DTXSID9020740;(1-p-Chlorobenzoyl-5-methoxy-2-methylindol-3-yl)acetic acid;1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid;1-(p-Chlorobenzoyl)-2-methoxy-3-methyl-1H-indole-3-acetic Acid;Indomet 140;EC 200-186-5;[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid;5-22-05-00239 (Beilstein Handbook Reference);{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid;NSC 757061;CAS-53-86-1;1-p-Cloro-benzoil-5-metoxi-2-metilindol-3-acido acetico;NCGC00015562-18;Indomethancin;1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid;Arthrexin;Bonidin;Bonidon;Indameth;Indomod;Miametan;SMR000058195;Indomo;Flexin continus;Hicin;Kwas 1-(p-chlorobenzoilo)-2-metylo-5-metoksy-3-indolilooctowy;Chrono-indicid;Chrono-indocid;Indometacyna [Polish];Indometicina [Spanish];2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid;Indo-Spray;Indomethacin (USAN:USP);Indolar SR;Indometacine (INN-French);Indometacinum (INN-Latin);Indometacina (INN-Spanish);INDOMETACIN (MART.);INDOMETACIN [MART.];DTXCID50740;INDOMETHACIN (USP-RS);INDOMETHACIN [USP-RS];1-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indoleacetic acid;INDOMETACIN (EP MONOGRAPH);INDOMETACIN [EP MONOGRAPH];INDOMETHACIN (USP MONOGRAPH);INDOMETHACIN [USP MONOGRAPH];2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetic acid;(1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL)ACETIC ACID;2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl}acetic acid;Indocin-SR;Indochron E-R;Indocin (TN);ACEMETACIN IMPURITY B (EP IMPURITY);ACEMETACIN IMPURITY B [EP IMPURITY];Aconip (TN);Indomethacin (USP);NSC77541;Indocid (pharmaceutical);SR-01000000014;Indomethacin & MAP-30;Indocollyre;Indonol;Innamit;1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-Indole-3-acetic acid;IndomethacinER;Indomethacin ER;2-{1-((4-chlorophenyl)carbonyl)-5-methoxy-2-methylindol-3-yl}acetic acid;4kyk;(1-((4-chlorophenyl)carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid;Indomethacin,(S);Prestwick_597;INDREN;Indometacinum (Latin);Opera_ID_56;Spectrum_000919;Tocris-1708;1z9h;1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-essigsaeure [German];1-p-Cloro-benzoil-5-metoxi-2-metilindol-3-acido acetico [Spanish];Prestwick0_000272;Prestwick1_000272;Prestwick2_000272;Prestwick3_000272;Spectrum2_000970;Spectrum3_000468;Spectrum4_000018;Spectrum5_000868;INDOMETACIN [JAN];INDOMETHACIN [MI];Lopac-I-7378;Kwas 1-(p-chlorobenzoilo)-2-metylo-5-metoksy-3-indolilooctowy [Polish];CHRONO-INDOCID 75;MolMap_000032;UPCMLD-DP023;I 7378;Indometacin (JP18/INN);INDOMETHACIN [HSDB];INDOMETHACIN [USAN];SCHEMBL9300;INDOMETHACIN [VANDF];Indomethacin Extended-release;Lopac0_000692;Oprea1_686105;BSPBio_000144;BSPBio_001149;BSPBio_002176;INDOMETACIN [WHO-DD];INDOMETACIN [WHO-IP];Indomethacine impurity mixture;KBioGR_000395;KBioGR_000489;KBioSS_000489;KBioSS_001399;MLS001074194;MLS006011845;BIDD:GT0132;DivK1c_000271;SPECTRUM1500350;SPBio_000979;SPBio_002363;BPBio1_000160;GTPL1909;Indomethacin, >=99% (TLC);UPCMLD-DP023:001;BDBM17638;CGIGDMFJXJATDK-UHFFFAOYSA-;HMS500N13;KBio1_000271;KBio2_000489;KBio2_001399;KBio2_003057;KBio2_003967;KBio2_005625;KBio2_006535;KBio3_000897;KBio3_000898;KBio3_001396;1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-essigsaeure;C01EB03;M01AB01;M02AA23;S01BC01;Indomethacin - CAS 53-86-1;NINDS_000271;Bio2_000405;Bio2_000885;HMS1362I11;HMS1568H06;HMS1792I11;HMS1920F21;HMS1990I11;HMS2089N19;HMS2091N09;HMS2095H06;HMS2231J10;HMS3262K05;HMS3268A14;HMS3374F07;HMS3403I11;HMS3414N13;HMS3430L03;HMS3649K17;HMS3655O04;HMS3678N11;HMS3712H06;HMS3747K21;HMS3884E08;INDOMETHACIN [ORANGE BOOK];Indomethacin-d4(chlorobenzoyl-d4);Pharmakon1600-01500350;BCP18951;Indomethacin, >=99.0% (TLC);Tox21_113109;Tox21_201791;Tox21_300266;Tox21_500692;AC-532;CCG-40186;HB4422;INDOMETACINUM [WHO-IP LATIN];NSC757061;s1723;STL257874;AKOS000592893;Tox21_113109_1;AT13679;DB00328;Indometacin 1.0 mg/ml in Acetonitrile;KS-5255;LP00692;SDCCGSBI-0050670.P005;IDI1_000271;IDI1_002160;NCGC00015562-01;NCGC00015562-02;NCGC00015562-03;NCGC00015562-04;NCGC00015562-05;NCGC00015562-06;NCGC00015562-07;NCGC00015562-08;NCGC00015562-09;NCGC00015562-10;NCGC00015562-11;NCGC00015562-12;NCGC00015562-13;NCGC00015562-14;NCGC00015562-15;NCGC00015562-16;NCGC00015562-17;NCGC00015562-19;NCGC00015562-20;NCGC00015562-21;NCGC00015562-22;NCGC00015562-24;NCGC00015562-25;NCGC00015562-40;NCGC00024135-02;NCGC00024135-04;NCGC00024135-05;NCGC00024135-06;NCGC00024135-07;NCGC00024135-08;NCGC00024135-09;NCGC00024135-10;NCGC00024135-11;NCGC00024135-12;NCGC00024135-13;NCGC00024135-14;NCGC00024135-15;NCGC00254075-01;NCGC00259340-01;NCGC00261377-01;BI166166;BP-30207;HY-14397;NCI60_041708;O-Desmethyl-des-4-chlorobenzoylacemetacin;SBI-0050670.P004;DB-052413;AB00052022;EU-0100692;I0655;NS00000217;SW196768-5;EN300-16807;Indomethacin, meets USP testing specifications;BIM-0050670.0001;C01926;D00141;S00108;AB00052022-20;AB00052022-21;AB00052022_23;AB00052022_24;L000959;Q409231;Indomethacin, Antibiotic for Culture Media Use Only;Q-201239;SR-01000000014-2;SR-01000000014-4;SR-01000000014-6;1-(4-Chlorobenzoyl)-5-methoxy-2-met hyl-1H-indole;BRD-K57222227-001-06-1;BRD-K57222227-001-18-6;BRD-K57222227-001-27-7;BRD-K57222227-001-28-5;BRD-K57222227-001-29-3;BRD-K57222227-001-30-1;SR-01000000014-10;SR-01000000014-16;Z56784896;1-p-chlorobenzoyl-2-methyl-5-methoxyindol-3-acetic acid;1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid;1-(p-Chlorobenzoyl)-5-methoxy-2-methylindol-3-acetic acid;1-(p-chlorobenzyl)-5-methoxy-2-methylindole-3-acetic acid;1-(4-chloro-benzoyl)-5-methoxy-2-methyl-3-indolyl-acetic acid;1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid;1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indole-acetic acid;1-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid;1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indol acetic acid;Indomethacin, European Pharmacopoeia (EP) Reference Standard;N-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid;1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1-H-indole-3-acetic acid;Indomethacin, United States Pharmacopeia (USP) Reference Standard;N-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID;.alpha.-(1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl)acetic acid;[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid #;1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid & MAP-30;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl- (9CI);2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2 methylindol-3-yl}acetic acid;2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2methylindol-3-yl}acetic acid;Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl- (8CI);Indomethacin, Pharmaceutical Secondary Standard; Certified Reference Material;InChI=1/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23);
IUPAC Name
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
Molecular Formula
C18H18O2
Canonical SMILES
C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C
InChI
InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
InChIKey
CGIGDMFJXJATDK-UHFFFAOYSA-N
Boiling Point
499.4°C at 760 mmHg
Toxicity
LD50: 50 mg/kg (oral, mice) (based on 14 day mortality response); LD50: 12 mg/kg (oral, rat) (based on 14 day mortality response).
