Hypaconitine

For Research Use Only.
Category
Alkaloids
Cat.No.
NP0562
CAS
6900-87-4
Product Name
Hypaconitine
Structure

Product Details

Description
Hypaconitine, a neuromuscular blocker, is a diterpene alkaloid found in the root of Aconitum carmichaelii. It is the primary constituent responsible for the neuromuscular blocking action of aconite root. It could inhibit CaM expression and Cx43 (Ser368) phosphorylation. It has anti-inflammatory effect.
Synonyms
(1-alpha,6-alpha,14-alpha,15-alpha,16-beta)-acetatebenzoat; 15-tetraol,16,16-trimethoxy-4-(methoxymethyl)-20-methyl-18-aconitane-14; Aconitane-8,13,14,15-tetrol,1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-,8-acetate 14-benzoate, (1α,6α,14α,15α,16β)-; (1α,6α,14α,15α,16β)1,6,16-TriMethoxy-4-(MethoxyMethyl)-20-Methylaconitane-8,13,14,15-tetrol 8-Acetate 14-Benzoate; Japaconitine B1; Deoxymesaconitine;
Molecular Weight
615.3
Molecular Formula
C33H45NO10
Canonical SMILES
CC(=O)OC12C3C(CC(C3OC(=O)C4=CC=CC=C4)(C(C1O)OC)O)C56C(CCC7(C5C(C2C6N(C7)C)OC)COC)OC
InChI
1S/C33H45NO10/c1-17(35)44-33-21-19(14-31(38,28(42-6)26(33)36)27(21)43-29(37)18-10-8-7-9-11-18)32-20(40-4)12-13-30(16-39-3)15-34(2)25(32)22(33)23(41-5)24(30)32/h7-11,19-28,36,38H,12-16H2,1-6H3/t19-,20+,21-,22+,23+,24-,25?,26+,27-,28+,30+,31-,32+,33-/m1/s1
InChIKey
FIDOCHXHMJHKRW-VHQVDBNASA-N
Melting Point
172-175 °C
Purity
>98%
Solubility
Soluble in DMSO
Appearance
White powder
Application
A neuromuscular blocker could inhibit CaM expression and Cx43 (Ser368) phosphorylation. It has anti-inflammatory effect.
Shelf Life
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Storage
Store at -20 °C
Color
Yellow
Form
Powder
Packaging
20 mg
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