Homoharringtonine

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For Research Use Only.

Category

Alkaloids

Cat.No.

NP0539

CAS

26833-87-4

Product Name

Homoharringtonine

Structure

Product Details

Description

Protein synthesis inhibitor. Selective 60S ribosome inhibitor. Prevents substrate binding to the acceptor site on the 60S ribosome subunit. Inhibits elongation phase of translation. Shows antitumor effects in vivo.

Synonyms

Omacetaxine mepesuccinate; HHT

Molecular Weight

545.62

Molecular Formula

C29H39NO9

Canonical SMILES

CC(C)(CCCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O

InChI

InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25+,28-,29?/m0/s1

InChIKey

HYFHYPWGAURHIV-ZEDNPHJLSA-N

Purity

>98%

Density

1.33 g/cm3

Appearance

Cryst.

Application

Anti-leukemic

Form

Powder

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