Homoharringtonine

For Research Use Only.
Category
Alkaloids
Cat.No.
NP0539
CAS
26833-87-4
Product Name
Homoharringtonine
Structure

Product Details

Description
Protein synthesis inhibitor. Selective 60S ribosome inhibitor. Prevents substrate binding to the acceptor site on the 60S ribosome subunit. Inhibits elongation phase of translation. Shows antitumor effects in vivo.
Synonyms
Omacetaxine mepesuccinate; HHT
Molecular Weight
545.62
Molecular Formula
C29H39NO9
Canonical SMILES
CC(C)(CCCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O
InChI
InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25+,28-,29?/m0/s1
InChIKey
HYFHYPWGAURHIV-ZEDNPHJLSA-N
Purity
>98%
Density
1.33 g/cm3
Appearance
Cryst.
Application
Anti-leukemic
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