HARRINGTONINE

Name: HARRINGTONINE
Brand: BOC Sciences
Rating: 5 (1 reviews)

Inquiry

For Research Use Only.

Category

Alkaloids

Cat.No.

NP0070

CAS

26833-85-2

Product Name

HARRINGTONINE

Structure

Product Details

Description

Harringtonine, isolated from Cephalotaxus harringtonia, inhibits protein synthesis at low micromolar concentrations and immobilizes ribosomes immediately after the initiation of translation.

Synonyms

2'R-Harringtonine; Alkaloid C from cephalotaxus; Harringtonin; NSC 124147; Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester)

Molecular Weight

531.59

Molecular Formula

C28H37NO9

Canonical SMILES

CC(C)(CCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O

InChI

1S/C28H37NO9/c1-26(2,32)8-9-28(33,15-22(30)35-4)25(31)38-24-21(34-3)14-27-7-5-10-29(27)11-6-17-12-19-20(37-16-36-19)13-18(17)23(24)27/h12-14,23-24,32-33H,5-11,15-16H2,1-4H3/t23?,24-,27+,28?/m0/s1

InChIKey

HAVJATCHLFRDHY-VZBLPSLPSA-N

Boiling Point

679.4±55.0 °C | Condition: Press: 760 Torr

Melting Point

73-75°C

Flash Point

364.7±31.5 °C

Purity

>98%

Density

1.35±0.1 g/cm3

Solubility

Soluble in DMSO

Appearance

White crystalline powder

Shelf Life

2 years

Storage

Store in a cool and dry place and at 0 - 4°C for short term (days to weeks) or -144°C for long term (months to years).

Color

Off-White to Pale Orange

Form

Solid

Hazard Class

6.1(a)

Packing Groups

pKa

11.62±0.29(Predicted)

RIDADR

1544

Uses

Specific anti-leukemia drug.

Vapor Pressure

0.0±2.2 mmHg at 25°C

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