Guaiacol

For Research Use Only.
Category
Phenols
Cat.No.
NP4574
CAS
90-05-1
Product Name
Guaiacol
Structure

Product Details

Description
Guaiacol is a phenolic natural product first isolated from Guaiac resin, as well as the oxidation of lignin. Guaiacol is an agent that is believed to have disinfecting properties and is used as an expectorant.
Synonyms
o-Methoxyphenol; 2-Hydroxyanisole; Phenol, 2-methoxy-; Pyroguaiac acid; Pyrocatechol monomethyl ether; 1-Hydroxy-2-methoxybenzene
IUPAC Name
2-methoxyphenol
Molecular Weight
124.14
Molecular Formula
C7H8O2
Canonical SMILES
COC1=CC=CC=C1O
InChI
InChI=1S/C7H8O2/c1-9-7-5-3-2-4-6(7)8/h2-5,8H,1H3
InChIKey
LHGVFZTZFXWLCP-UHFFFAOYSA-N
Boiling Point
greater than or equal to 397.4 °F at 760 mmHg
Melting Point
less than -4 °F
Flash Point
165 °F
Density
greater than 1.076 at 77 °F
Solubility
Soluble in Chloroform (Slightly), Methanol (Slightly)
Appearance
Colorless to Pale Orange Oil to Low-Melting Solid
Storage
4°C, Inert atmosphere, Light sensitive
BRN
508112
Chemical Properties
Guaiacol has a characteristic sweet odor. It is slightly phenolic.
Color
Clear colorless to light yellow
Definition
ChEBI: A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.
EINECS
201-964-7
Form
Liquid After Melting
Hazard Class
Xn,T,Xi
Hazard Codes
6.1(b)
HS Code
29095010
Packing Groups
II
pH
5.4 (10g/L, H2O, 20 °C)
pKa
9.98(at 25 °C)
Purification Methods
Crystallise guaiacol from *benzene/pet ether or distil it in a vacuum.
Refractive Index
1.5429 at 20 °C/D
RIDADR
2810
Risk Statements
22-36/38
RTECS
SL7525000
Safety Statements
26
Stability
Soln deposits calcium hydroxide & calcium carbonate on standing
Toxicity
LD50 orally in rats: 725 mg/kg (Taylor)
Uses
Guaiacol is a precursor of vanillin and santalidol (a synthetic sandal-
wood fragrance). it is obtained from wood tar by the destructive
distillation of hardwood, by the distillation of the phenol fraction
of coal tar, or through the use of o-dichlorobenzene. it is processed
to yield vanillin.
Vapor Density
4.27 (vs air)
Vapor Pressure
0.11 mm Hg ( 25 °C)
Water Solubility
17 g/L (15 °C)
WGK Germany
1
  • Verification code
Online Inquiry
  • Verification code
×
Top
Inquiry Basket