Griffipavixanthone

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For Research Use Only.

Size	Price	Stock	Quantity
1 mg	$519	In stock

Category

Xanthones

Cat.No.

NP7252

CAS

219649-95-3

Product Name

Griffipavixanthone

Structure

Product Details

Description

Griffipavixanthone is a natural xanthone found in the fruits of Garcinia oblongifolia Champ, it inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, with IC50 values of 3.03 ± 0.21 μM at 48h, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production; which demonstrates that the potential application of griffipavixanthone as an anti-non-small cell lung cancer agent.

Synonyms

Indeno[1,2-a]xanthen-13(8H)-one,8a,9,10,12a-tetrahydro-1,3,6,7-tetrahydrox
y-9,9,11-trimethyl-8-(3,4,6,8-tetrahydroxy-9-oxo-9H-xanthen-1-yl)-,(8R,8aR,12aS)-rel-(+)-

IUPAC Name

(8S,8aS,12aR)-1,3,6,7-tetrahydroxy-9,9,11-trimethyl-8-(3,4,6,8-tetrahydroxy-9-oxoxanthen-1-yl)-8,8a,10,12a-tetrahydroindeno[1,2-a]xanthen-13-one

Molecular Weight

652.6

Molecular Formula

C36H28O12

Canonical SMILES

CC1=CC2C(C(C3=C(C(=C4C(=C23)C(=O)C5=C(C=C(C=C5O4)O)O)O)O)C6=CC(=C(C7=C6C(=O)C8=C(C=C(C=C8O7)O)O)O)O)C(C1)(C)C

InChI

InChI=1S/C36H28O12/c1-11-4-15-21-26(32(45)33(46)35-27(21)31(44)25-17(40)6-13(38)8-20(25)48-35)22(28(15)36(2,3)10-11)14-9-18(41)29(42)34-23(14)30(43)24-16(39)5-12(37)7-19(24)47-34/h4-9,15,22,28,37-42,45-46H,10H2,1-3H3/t15-,22-,28-/m0/s1

InChIKey

KAPVRSRPLHVWCH-JNFGOLMQSA-N

Boiling Point

862.8±65.0 °C(Predicted)

Purity

>98%

Density

1.630±0.06 g/cm3(Predicted)

Appearance

Brown powder

Application

anti-non-small cancer

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