Glaucocalyxin A

Inquiry

For Research Use Only.

Size	Price	Stock	Quantity
10 mg	$439	In stock

Category

Diterpenoids

Cat.No.

NP1506

CAS

79498-31-0

Product Name

Glaucocalyxin A

Structure

Product Details

Description

Glaucocalyxin A, which is extracted from the herbs of Rabdosia rubescens, inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein. Glaucocalyxin A inhibited collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway.

Synonyms

LeukaMenin F; Wangzaozin B; Leucamenin F

IUPAC Name

(1R,2R,4S,9R,10S,13S,16R)-2,16-dihydroxy-5,5,9-trimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-6,15-dione

Molecular Weight

332.43

Molecular Formula

C20H28O4

Canonical SMILES

CC1(C2CC(C34C(C2(CCC1=O)C)CCC(C3O)C(=C)C4=O)O)C

InChI

InChI=1S/C20H28O4/c1-10-11-5-6-12-19(4)8-7-14(21)18(2,3)13(19)9-15(22)20(12,16(10)23)17(11)24/h11-13,15,17,22,24H,1,5-9H2,2-4H3/t11-,12-,13+,15+,17+,19-,20-/m0/s1

InChIKey

UCDVIBNDYLUWFP-MJTHGBBVSA-N

Purity

>98%

Density

1.22±0.1 g/cm3

Appearance

White powder

Application

Antiplatelet/antithrombotic

Form

Powder