Glabridin

Flavonoids

NP1938

59870-68-7

Glabridin

Glabridin is a bio-available isoflavan isolated from licorice (Glycyrrhiza glabra L.) root extract. It has been reported to possess various biological activities, including strong antioxidant activity, anti-LDL oxidation, anti-Helicobacter pylori properties, estrogen-like activity, anti-nephropathy, and free radical scavenging activity. It retains anti-inflammatory abilities to regulate the synthesis and activity of iNOS under high-glucose levels, implying that a Glabridin supplement may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction. It inhibited the invasion of human HCC cells and may have potential as a chemopreventive agent against liver cancer metastasis. It exhibits antiplasmodial activity and is suitable for developing antimalarial agent from a cheap and sustainable source. It may possess a therapeutic effect on metabolic disorders, such as diabetes and hyperglycemia, by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin is also a key ingredient used in cosmetics. It has whitening, anti-inflammatory, antibacterial and antioxidant effects.

4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]benzene-1,3-diol; 4-((R)-8,8-Dimethyl-3,4-dihydro-2H,8H-benzo[1,2-B:4,3-B']dipyran-3-yl)-benzene-1,3-diol; (R)-4-(8,8-dimethyl-2,3,4,8-tetrahydropyrano[2,3-f]chromen-3-yl)benzene-1,3-diol; (R)-Glabridin

4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol

324.37

C20H20O4

CC1(C=CC2=C(O1)C=CC3=C2OCC(C3)C4=C(C=C(C=C4)O)O)C

InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1

LBQIJVLKGVZRIW-ZDUSSCGKSA-N

518.6±50.0°C at 760 Torr

154-155°C

>98%

1.257±0.06 g/cm3 (Predicted)

Soluble in DMSO

White to light brown powder

Store at RT

Yellow

Powder

20 mg