Description
Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM.
Synonyms
Ginkgolide A; BN 52020; BN 52020; BN-52020;
IUPAC Name
8-tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione
Molecular Formula
C20H24O9
Canonical SMILES
CC1C(=O)OC2C1(C34C(=O)OC5C3(C2)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O
InChI
InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3
InChIKey
FPUXKXIZEIDQKW-UHFFFAOYSA-N
Boiling Point
710.1±60.0 °C(Predicted)
Melting Point
280°C (dec.)
Density
1.56±0.1 g/cm3(Predicted)
Solubility
Soluble in DMSO
Storage
Inert atmosphere,Store in freezer, under -20°C
Alpha
D24 -53.4° (c = 1 in ethanol)
Chemical Properties
Crystalline Solid
pKa
11.45±0.70(Predicted)
Uses
Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists.