Gefitinib

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For Research Use Only.

Size	Price	Stock	Quantity
5 g	$159	In stock
10 g	$259	In stock

Category

Impurities

Cat.No.

NP3246

CAS

184475-35-2

Product Name

Gefitinib

Structure

Product Details

Description

Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition.

Synonyms

ZD1839; ZD 1839; ZD-1839; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine; Iressa; gefitinibum

IUPAC Name

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine

Molecular Weight

446.90

Molecular Formula

C22H24ClFN4O3

Canonical SMILES

COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

InChI

InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)

InChIKey

XGALLCVXEZPNRQ-UHFFFAOYSA-N

Boiling Point

586.8±50.0°C (Predicted)

Melting Point

192-194°C

Purity

>98%

Density

1.322±0.06 g/cm3 (Predicted)

Solubility

Slightly soluble in DMSO, Methanol (Heated)

Appearance

White to Off-white Solid

Storage

Store at -20°C

Form

Powder

Packaging

5 g / 10 g

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