Description
5-Fluorocytosine, a fluorinated pyrimidine analogue, is a synthetic antifungal medication.
Synonyms
Flucytosine; Flucytosin; Ancobon; Ancotil; 4-Amino-5-fluoro-2(1H)-pyrimidine; 5-FC; NSC 103805; 6-Amino-5-fluoro-2(1H)-pyrimidinone
IUPAC Name
6-amino-5-fluoro-1H-pyrimidin-2-one
Molecular Formula
C4H4FN3O
Canonical SMILES
C1=NC(=O)NC(=C1F)N
InChI
InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
InChIKey
XRECTZIEBJDKEO-UHFFFAOYSA-N
Melting Point
295-297°C (dec.)
Solubility
Slightly soluble in Aqueous Base, DMSO (Heated), Methanol (Heated)
Application
Antifungal agents; antimetabolites
Storage
Store at 2-8°C protect from light
Toxicity
LD50: 15 gm/kg (Oral, Rat).