Fludarabine

Inquiry

For Research Use Only.

Category

Impurities

Cat.No.

NP3321

CAS

21679-14-1

Product Name

Fludarabine

Structure

Product Details

Description

Arabinofuranosyl-2-fluoro-adenin is an adenosine deaminase resistant analog of 9-β-D-arabinofuranosyladenine (ara-A) that inhibits DNA synthesis. It is commonly used as an antitumor agent for its antiproliferative property.

Synonyms

2-F-Ara-Ar; 2-Fluoro-arabinoadenosine; 9-(β-D-Arabinofuranosyl)-2-fluoroadenine; F-ara-A; NSC 118218; (2R,3S,4S,5R)-2-(6-Amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; 2-fluoro-9-β-D-arabinofuranosyladenine

IUPAC Name

(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Molecular Weight

285.23

Molecular Formula

C10H12FN5O4

Canonical SMILES

C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(N=C2N)F

InChI

InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1

InChIKey

HBUBKKRHXORPQB-FJFJXFQQSA-N

Boiling Point

747.3±70.0°C (Predicted)

Melting Point

>256°C (dec.)

Flash Point

405.8°C

Purity

≥95%

Density

2.17±0.1 g/cm3 (Predicted)

Solubility

Soluble in DMF, DMSO, Methanol, Ethanol, Water (Sparingly)

Appearance

White to Off-white Crystals

Application

Antineoplastic Agents

Storage

Store at 2-8°C

Form

Powder

Refractive Index

1.876

Risk Statements

R23/24/25; R36/37/38; R39

Safety Statements

S26-S36/37-S45

Vapor Pressure

1.86E-23mmHg at 25°C

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