Euphohelioscopin A

Diterpenoids

NP1734

87064-61-7

Euphohelioscopin A

Euphohelioscopin A is extracted from the herbs of Euphorbia helioscopia. It shows moderate inhibitory activity on the release of IL-6, chemokine MCP-1 and cytokine TNF-α with IC50 values of 46.1± 1.1, 33.7±3.8 and 23.7 ± 1.7 uM in lipopolysaccharide (LPS) induced RAW 264.7 macrophages, but displays no notable cytotoxicity. It inhibits proliferation and induces differentiation of the myeloid leukemia cell lines HL-60 and THP-1. It is an activator of protein kinase C (PKC).

(1aR,2Z,4aR,6R,7S,7aS,8Z,10R,11aS)-4a-Acetoxy-7-hydroxy-1,1,3,6,9-pentamethyl-4-oxo-1a,4,4a,5,6,7,7a,10,11,11a-decahydro-1H-cyclopenta[a]cyclopropa[f][11]annulen-10-yl (2E,4Z)-2,4-octadienoate

(1-acetyloxy-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxo-9-tricyclo[10.3.0.05,7]pentadeca-3,10-dienyl) octa-2,4-dienoate

498.66

C30H42O6

CCCC=CC=CC(=O)OC1CC2C(C2(C)C)C=C(C(=O)C3(CC(C(C3C=C1C)O)C)OC(=O)C)C

InChI=1S/C30H42O6/c1-8-9-10-11-12-13-26(32)35-25-16-23-22(29(23,6)7)15-19(3)28(34)30(36-21(5)31)17-20(4)27(33)24(30)14-18(25)2/h10-15,20,22-25,27,33H,8-9,16-17H2,1-7H3

LVWCGFQTAFKQBI-UHFFFAOYSA-N

96.5%

Powder

Yellow

Powder