Eriocalyxin B

Diterpenoids

NP1304

84745-95-9

Eriocalyxin B

Eriocalyxin B, isolated from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor. Eriocalyxin B inhibited the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein. eriocalyxin B reversibly interfered with the binding of p65 and p50 subunits to the DNA in a noncompetitive manner. Eriocalyxin B exerts potent antiinflammatory effects through selective modulation of pathogenic Th1 and Th17 cells by targeting critical signaling pathways. Besides, Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways. Eriocalyxin B should be considered a candidate for pancreatic cancer treatment.

Rabdosianone

344.4

C20H24O5

551.1±50.0 °C(Predicted)

>98%

1.37±0.1 g/cm3(Predicted)

Powder

Antiinflammatory

Powder

1 mg

11.05±0.60(Predicted)