Epieriocalyxin A

Diterpenoids

NP1352

191545-24-1

Epieriocalyxin A

Epieriocalyxin A (EpiA), a diterpenoid isolated from I. eriocalyx, suppressed Caco-2 colon cancer cell growth. Western blot results showed that both JNK and ERK1/2 activation was decreased after Epieriocalyxin A treatment in a dose-dependent manner. Epieriocalyxin A increased the expression of caspase 3 and Bax, and decreased Bcl2 expression. Our results suggest that Epieriocalyxin A is a novel compound that induces colon cancer apoptosis. Epieriocalyxin A could be a potential drug for colon cancer therapy in the future.

Spiro[1H-7,9a-methanolocyclohepta[c]pyran-4(3H),1'-[3]cyclohexene]-6'-carboxaldehyde, 4a,5,6,7,8,9-hexahydro-5',5',8-trimethyl-1,2',9-trioxo-, (1'S,4aS,6'R,7R,8R,9aS)-

(1S,1'R,5S,6S,9R)-2',2',10-trimethyl-2,5',11-trioxospiro[3-oxatricyclo[7.2.1.01,6]dodecane-5,6'-cyclohex-3-ene]-1'-carbaldehyde

344.4

C20H24O5

CC1C2CCC3C(C2)(C1=O)C(=O)OCC34C(C(C=CC4=O)(C)C)C=O

InChI=1S/C20H24O5/c1-11-12-4-5-13-19(8-12,16(11)23)17(24)25-10-20(13)14(9-21)18(2,3)7-6-15(20)22/h6-7,9,11-14H,4-5,8,10H2,1-3H3/t11?,12-,13-,14-,19+,20+/m1/s1

NTFGUZQAIRRLSN-BJXJFWQYSA-N

>98%

Powder

Anti-cancer

Powder

1 mg