Description
Diosbulbin D is a natural diterpenoid found in the roots of Dioscorea bulbifera. It shows toxic effect on hepatocytes.
Synonyms
(2S)-2β-(3-Furyl)-4aα,5,6aβ,7,10,11,11aα,11b-octahydro-11bβ-methyl-7β,10β-methano-2H-pyrano[4,3-g][3]benzoxepine-4,6,8(1H)-trione
IUPAC Name
8-(furan-3-yl)-10-methyl-7,14-dioxatetracyclo[11.2.1.02,11.05,10]hexadecane-3,6,15-trione
Molecular Formula
C19H20O6
Canonical SMILES
CC12CC(OC(=O)C1CC(=O)C3C2CC4CC3C(=O)O4)C5=COC=C5
InChI
InChI=1S/C19H20O6/c1-19-7-15(9-2-3-23-8-9)25-18(22)13(19)6-14(20)16-11-4-10(5-12(16)19)24-17(11)21/h2-3,8,10-13,15-16H,4-7H2,1H3
InChIKey
FJCWYLRNGKSUCH-UHFFFAOYSA-N
Application
cytotoxic activity
Uses
Diosbulbin D has shown to induce cytotoxicity against human hepatocellular carcinoma cells, apoptosis in normal human liver L-02 cells, and constitutes of anti-inflammatory properties.