Dihydroguaiaretic acid

Lignans

NP3978

66322-34-7

Dihydroguaiaretic acid

Meso-dihydroguaiarectic acid (MDGA), coming from the aerial parts of Saururus chinensis, significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress, via antioxidative activities. It might provide a basis for novel anti-inflammatory drug development. Meso-dihydroguaiaretic acid (MDGA) inhibits the cyclooxygenase-2 (COX-2)-dependent phase of prostaglandin D2 (PGD2) generation in bone marrow-derived mast cells (BMMC) (IC50 9.8 μM). Besides, Dihydroguaiaretic acid (DHGA) showed an inhibitory effect against the complex formation of the fos-jun dimer and the DNA consensus sequence with an IC50 value of 0.21 micromol. DHGA suppressed leukemia, lung cancer and colon cancer in an in vitro bioassay.

Meso-dihydroguaiaretic acid

4-[(2S,3R)-4-(4-hydroxy-3-methoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol

330.4

C20H26O4

CC(CC1=CC(=C(C=C1)O)OC)C(C)CC2=CC(=C(C=C2)O)OC

InChI=1S/C20H26O4/c1-13(9-15-5-7-17(21)19(11-15)23-3)14(2)10-16-6-8-18(22)20(12-16)24-4/h5-8,11-14,21-22H,9-10H2,1-4H3/t13-,14+

ADFOLUXMYYCTRR-OKILXGFUSA-N

488.3±40.0 °C(Predicted)

88-89 °C

>98%

1.121±0.06 g/cm3(Predicted)

Soluble in Chloroform,Dichloromethanole,Ethyl Acetate,DMSO,Acetone,etc.

Powder

Antioxidative/anti-inflammatory

MFCD02752706

9.89±0.20(Predicted)

Dihydroguaiaretic Acid exhibits antibacterial activity against a gram negative bacterium. Also, it has various biological activities, including anti-oxidative, anti-inflammatory, antibacterial and neuroprotective effects.