Desloratadine

Impurities

NP3209

100643-71-8

Desloratadine

Desloratadine is a potent antagonist for human histamine H1 receptor with IC50 of 51 nM.

8-Chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Loratadine EP Impurity D; SCH-34117; SCH 34117; SCH34117; NSC 675447; NSC675447; NSC-675447; 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene)-; 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 8-Chloro-11-(4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Aerius; Allex; Azomyr; Clarinex; Dasselta; Delopedil; Descarboethoxyloratadine; Descarboethoxyloratidine; Desler; Eurodesa; Neoclarityn; Opulis; Sedno; USP Loratadine Related Compound A; Loratadine USP Related Compound A; 8-Chloro-5,6-dihydro-11-(piperidin-4-ylidene)-11H-benzo[5,6]cyclohepta[1,2-b]pyridine; Loratadine related compound A

13-chloro-2-piperidin-4-ylidene-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene

310.82

C19H19ClN2

C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4

InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

JAUOIFJMECXRGI-UHFFFAOYSA-N

467.9±45.0°C at 760 mmHg

150-151°C

>98%

1.221±0.06 g/cm3

Soluble in Chloroform (Slightly), Ethyl Acetate (Slightly)

Off-White to Beige Solid

Histamine H1 Antagonists, Non-Sedating

Store at -20°C

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