De-O-methyllasiodiplodin

Phenols

NP4707

32885-82-8

De-O-methyllasiodiplodin

De-O-methyllasiodiplodin is a natural compound isolated from the rhizomes of Smilax glabra. De-O-methyllasiodiplodin exhibits radical scavenging and moderate antibacterial effects. It effectively lowers the blood glucose level in db/db mice possibly via ameliorating the expression of obesity-related pro-inflammatory cytokines, highlighting the potential of the marine natural product as a drug lead for the treatment of metabolic disorders. De-O-methyllasiodiplodin shows moderate suppression effects on induced NO production, suggesting that it has potential anti-inflammatory activity.

(9S)-13,15-dihydroxy-9-methyl-10-oxabicyclo[10.4.0]hexadeca-1(12),13,15-trien-11-one

(4S)-14,16-dihydroxy-4-methyl-3-oxabicyclo[10.4.0]hexadeca-1(12),13,15-trien-2-one

278.34

C16H22O4

CC1CCCCCCCC2=CC(=CC(=C2C(=O)O1)O)O

InChI=1S/C16H22O4/c1-11-7-5-3-2-4-6-8-12-9-13(17)10-14(18)15(12)16(19)20-11/h9-11,17-18H,2-8H2,1H3/t11-/m0/s1

NFEVFCAOVZCHBN-NSHDSACASA-N

120-125 °C (hexane )

Powder

Mineralocorticoid Receptor Antagonists