Description
Daurisoline could inhibit EADs which may be associated with its blockade effects on I(Ca-L).
Synonyms
Daurisoline; (1R)-1,2,3,4-Tetrahydro-1-[[4-hydroxy-3-[4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol; (R,R)-Daurisoline; O7-Demethyldauricine
Molecular Formula
C37H42N2O6
Canonical SMILES
CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)O)O)OC)OC
InChI
1S/C37H42N2O6/c1-38-15-13-26-20-36(43-4)37(44-5)22-29(26)30(38)16-23-6-9-27(10-7-23)45-35-18-24(8-11-32(35)40)17-31-28-21-33(41)34(42-3)19-25(28)12-14-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31-/m1/s1
InChIKey
BURJAQFYNVMZDV-FIRIVFDPSA-N
Boiling Point
724.5±60.0°C (Predicted)
Density
1.218±0.06 g/cm3(Predicted)
Solubility
DMSO: 15 mg/mL, clear
Application
cytoprotective
Uses
Daurisoline is a bisbenzylisoquinoline alkaloid isolated from menispermum dauricum and displays antiarrythmic effects.