Description
Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.
Synonyms
Daphnetin; NSC 633563; Daphnetol; Ruixiangsu; 7,8-Dihydroxy-2H-1-benzopyran-2-one; 7,8-Dihydroxy-2H-chromen-2-one
IUPAC Name
7,8-dihydroxychromen-2-one
Canonical SMILES
C1=CC(=C(C2=C1C=CC(=O)O2)O)O
InChI
InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
InChIKey
ATEFPOUAMCWAQS-UHFFFAOYSA-N
Boiling Point
430.4±45.0°C at 760 mmHg
Melting Point
265-268°C (dec.)
Solubility
Soluble in DMSO, Ethanol