Cyproheptadine hydrochloride

Impurities

NP3348

969-33-5

Cyproheptadine hydrochloride

Cyproheptadine is a non-selective histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM. It is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It is also SETD7/9 inhibitor with IC50 value of 1μM. It decreases expression and increases degradation of estrogen receptor (ER) α in breast tumor MCF7 cells. It is used as antipruritic, antiallergic, appetite stimulant, and for the post-gastrectomy dumping syndrome and so on. It is also useful for migraine prophylactic.

Periactin hydrochloride;Cyproheptadine Hcl;4-(Dibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-1-methylpiperidine hydrochloride

323.86

C21H22ClN

CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.Cl

InChI=1S/C21H21N.ClH/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;/h2-11H,12-15H2,1H3;1H

ZPMVNZLARAEGHB-UHFFFAOYSA-N

254-256.5 °C | Condition: Solv: ethanol (64-17-5); ethyl ether (60-29-7)

>98 %

DMSO 65 mg/mL; Water <1 mg/Ml

Solid powder

Cyproheptadine has local anesthetic properties. It is used as antipruritic, antiallergic, appetite stimulant, and for the post-gastrectomy dumping syndrome and so on. It is also useful for migraine prophylactic.

2 month in rt, long time

-20°C Freezer