CYCLO(-GLY-PRO)

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For Research Use Only.

Category

Alkaloids

Cat.No.

NP0059

CAS

3705-27-9

Product Name

CYCLO(-GLY-PRO)

Structure

Product Details

Description

Cyclo(Gly-L-Pro) is a cyclodipeptide isolated from the roots of Panax notoginseng (Burk.)F.H.Chen. Cyclo(Gly-L-Pro) was reported to inhibit TNF-α release, IL-1β and IL-6 mRNA expression and NO production.

Synonyms

(S)-Hexahydropyrrolo[1,2-a]pyrazine-1,4-dione; (8aS)-octahydropyrrolo[1,2-a]piperazine-1,4-dione

IUPAC Name

(8aS)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Molecular Weight

154.169

Molecular Formula

C7H10N2O2

Canonical SMILES

C1CC2C(=O)NCC(=O)N2C1

InChI

InChI=1S/C7H10N2O2/c10-6-4-8-7(11)5-2-1-3-9(5)6/h5H,1-4H2,(H,8,11)/t5-/m0/s1

InChIKey

OWOHLURDBZHNGG-YFKPBYRVSA-N

Boiling Point

447.855°C at 760 mmHg

Melting Point

220-223°C

Density

1.325 g/cm3

Solubility

Soluble in DMSO

Appearance

Powder

Storage

Store at -20°C

Color

Clear slightly brown

Form

Liquid

pKa

13.21±0.20(Predicted)

Uses

CYCLO(-GLY-PRO) and its derivatives can be used as cyclic dipeptide chitinase inhibitors. It is also used to synthesize 5-HT1A receptor agonists.

WGK Germany

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