Curculigoside

For Research Use Only.
Category
Phenols
Cat.No.
NP4626
CAS
85643-19-2
Product Name
Curculigoside
Structure

Product Details

Description
Curculigoside, isolated from the rhizomes of Curculigo orchioides Gaertn, improved osteogenesis and inhibited osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disorders. It can promote calcium deposition and increase the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character. Besides, Curculigoside can protect endothelial cells against oxidative injury induced by H(2)O(2), suggesting that this compound may constitute a promising intervention against cardiovascular disorders.
Synonyms
2-[[(2,6-Dimethoxybenzoyl)oxy]methyl]-4-hydroxyphenyl b-D-glucopyranoside; Curculigoside A
IUPAC Name
[5-hydroxy-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl 2,6-dimethoxybenzoate
Molecular Weight
466.44
Molecular Formula
C22H26O11
Canonical SMILES
COC1=C(C(=CC=C1)OC)C(=O)OCC2=C(C=CC(=C2)O)OC3C(C(C(C(O3)CO)O)O)O
InChI
InChI=1S/C22H26O11/c1-29-14-4-3-5-15(30-2)17(14)21(28)31-10-11-8-12(24)6-7-13(11)32-22-20(27)19(26)18(25)16(9-23)33-22/h3-8,16,18-20,22-27H,9-10H2,1-2H3/t16-,18-,19+,20-,22-/m1/s1
InChIKey
SJJRKHVKAXVFJQ-QKYBYQKWSA-N
Boiling Point
734.9±60.0 °C(Predicted)
Melting Point
158-160 °C(Solv: methanol (67-56-1))
Purity
>98%
Density
1.450±0.06 g/cm3(Predicted)
Solubility
methanol (Slightly)
Appearance
Powder
Application
Antioxidant
Storage
-20°C Freezer
Color
Off-White
Form
Solid
HS Code
29389090
pKa
9.70±0.20(Predicted)
Safety Statements
24/25
Uses
Curculigoside induces angiogenesis through Vcam-1/Egr-3/CREB/VEGF signal pathway. May aid in protecting the brain against injury. In addition it improves osteogenesis of human amniotic fluid derived stem cells.
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