Curculigoside

Inquiry

For Research Use Only.

Category

Phenols

Cat.No.

NP4626

CAS

85643-19-2

Product Name

Curculigoside

Structure

Product Details

Description

Curculigoside, isolated from the rhizomes of Curculigo orchioides Gaertn, improved osteogenesis and inhibited osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disorders. It can promote calcium deposition and increase the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character. Besides, Curculigoside can protect endothelial cells against oxidative injury induced by H(2)O(2), suggesting that this compound may constitute a promising intervention against cardiovascular disorders.

Synonyms

2-[[(2,6-Dimethoxybenzoyl)oxy]methyl]-4-hydroxyphenyl b-D-glucopyranoside; Curculigoside A

IUPAC Name

[5-hydroxy-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl 2,6-dimethoxybenzoate

Molecular Weight

466.44

Molecular Formula

C22H26O11

Canonical SMILES

COC1=C(C(=CC=C1)OC)C(=O)OCC2=C(C=CC(=C2)O)OC3C(C(C(C(O3)CO)O)O)O

InChI

InChI=1S/C22H26O11/c1-29-14-4-3-5-15(30-2)17(14)21(28)31-10-11-8-12(24)6-7-13(11)32-22-20(27)19(26)18(25)16(9-23)33-22/h3-8,16,18-20,22-27H,9-10H2,1-2H3/t16-,18-,19+,20-,22-/m1/s1

InChIKey

SJJRKHVKAXVFJQ-QKYBYQKWSA-N

Boiling Point

734.9±60.0 °C(Predicted)

Melting Point

158-160 °C(Solv: methanol (67-56-1))

Purity

>98%

Density

1.450±0.06 g/cm3(Predicted)

Solubility

methanol (Slightly)

Appearance

Powder

Application

Antioxidant

Storage

-20°C Freezer

Color

Off-White

Form

Solid

HS Code

29389090

pKa

9.70±0.20(Predicted)

Safety Statements

24/25

Uses

Curculigoside induces angiogenesis through Vcam-1/Egr-3/CREB/VEGF signal pathway. May aid in protecting the brain against injury. In addition it improves osteogenesis of human amniotic fluid derived stem cells.

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