Cucurbitacin B

Inquiry

For Research Use Only.

Category

Triterpenoids

Cat.No.

NP7003

CAS

6199-67-3

Product Name

Cucurbitacin B

Structure

Product Details

Description

Cucurbitacin B, which can be extracted from the rhizomes of Hemsleya amabilis Diels, has profound in vitro and in vivo antiproliferative effects against human pancreatic cancer cells. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells. It is also an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity.

Synonyms

(2beta,9beta,10alpha,16alpha,23e)-thyl; 19-nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione,2-beta,16-alpha,20,25; 19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet; 19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me; 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-tr; cucurbitacineb; AMARINE; 1,2-DIHYDRO-ALPHA-ELATERIN

Molecular Weight

558.7

Molecular Formula

C32H46O8

Canonical SMILES

CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3CC(C(=O)C4(C)C)O)C)C)C)O)O

Purity

>98%

Solubility

DMSO,100mg/mL(178.98mM);Ethanol,50mg/mLwarmed(89.49mM);Water,<1mg/mL(<1mM)

Appearance

White powder

Application

Antiproliferative

Shelf Life

2 years if stored properly

Storage

3 years -20°Cpowder;6 months-80°Cin solvent

Form

Powder

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