Cryptofolione

Phenols

NP4695

160098-78-2

Cryptofolione

Cryptofolione is purified from the fruits of Cryptocarya alba. Cryptofolione shows moderate cytotoxicity in both macrophages and T. cruzi amastigotes, and also displays a mild inhibitory effect on the promastigote form of Leishmania spp. Z-Cryptofolione and Cryptomoscatone D2 acts as highly efficacious inhibitors of the G(2) checkpoint, and G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage to enter mitosis.

(2R)-2-[(1E,4S,6R,7E)-4,6-dihydroxy-8-phenylocta-1,7-dienyl]-2,3-dihydropyran-6-one

314.38

C19H22O4

C1C=CC(=O)OC1C=CCC(CC(C=CC2=CC=CC=C2)O)O

InChI=1S/C19H22O4/c20-16(8-4-9-18-10-5-11-19(22)23-18)14-17(21)13-12-15-6-2-1-3-7-15/h1-7,9,11-13,16-18,20-21H,8,10,14H2/b9-4+,13-12+/t16-,17-,18-/m0/s1

JSKFCRSAYKODTM-RURAAYBUSA-N

Oil