Crebanine

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For Research Use Only.

Size	Price	Stock	Quantity
10 mg	$298	In stock

Category

Alkaloids

Cat.No.

NP0347

CAS

25127-29-1

Product Name

Crebanine

Structure

Product Details

Description

Crebanine is isolated from the herbs of Stephania yunnanensis. Crebanine might be used as the starting point to develop a drug for Alzheimer's disease, having potential utility of crebanine in the development of neurodegenerative therapy. Inhibiting the proliferation of human leukemic cells (HL-60, U937 and K562), human fibrosarcoma cells (HT1080) and cervix cancer cell lines (KB-3-1 and KB-V1), Crebanine has anti-cancer activity.

Synonyms

Crebanin; 8,9-Dimethoxy-1,2-methylenedioxyaporphine

IUPAC Name

15,16-dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaene

Molecular Weight

339.4

Molecular Formula

C20H21NO4

Canonical SMILES

CN1CCC2=CC3=C(C4=C2C1CC5=C4C=CC(=C5OC)OC)OCO3

InChI

InChI=1S/C20H21NO4/c1-21-7-6-11-8-16-20(25-10-24-16)18-12-4-5-15(22-2)19(23-3)13(12)9-14(21)17(11)18/h4-5,8,14H,6-7,9-10H2,1-3H3

InChIKey

UVDQDNQWGQFIAO-UHFFFAOYSA-N

Boiling Point

488.2±45.0°C (Predicted)

Melting Point

126°C

Purity

97%

Density

1.266g/cm3

Appearance

Cryst.

Application

antiarrhythmic; anti-tumor; anti-cancer

EINECS

200-258-5

Form

Powder

Packaging

10 mg

Uses

Crebanine is an aporphine alkaloid which helps sensitize TNF-α induced apoptosis and suppress human lung adenocarcinoma.

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