Crebanine

For Research Use Only.
Category
Alkaloids
Cat.No.
NP0347
CAS
25127-29-1
Product Name
Crebanine
Structure

Product Details

Description
Crebanine is isolated from the herbs of Stephania yunnanensis. Crebanine might be used as the starting point to develop a drug for Alzheimer's disease, having potential utility of crebanine in the development of neurodegenerative therapy. Inhibiting the proliferation of human leukemic cells (HL-60, U937 and K562), human fibrosarcoma cells (HT1080) and cervix cancer cell lines (KB-3-1 and KB-V1), Crebanine has anti-cancer activity.
Synonyms
Crebanin; 8,9-Dimethoxy-1,2-methylenedioxyaporphine
IUPAC Name
15,16-dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaene
Molecular Weight
339.4
Molecular Formula
C20H21NO4
Canonical SMILES
CN1CCC2=CC3=C(C4=C2C1CC5=C4C=CC(=C5OC)OC)OCO3
InChI
InChI=1S/C20H21NO4/c1-21-7-6-11-8-16-20(25-10-24-16)18-12-4-5-15(22-2)19(23-3)13(12)9-14(21)17(11)18/h4-5,8,14H,6-7,9-10H2,1-3H3
InChIKey
UVDQDNQWGQFIAO-UHFFFAOYSA-N
Boiling Point
488.2±45.0°C (Predicted)
Melting Point
126°C
Purity
97%
Density
1.266g/cm3
Appearance
Cryst.
Application
antiarrhythmic; anti-tumor; anti-cancer
EINECS
200-258-5
Form
Powder
Packaging
10 mg
Uses
Crebanine is an aporphine alkaloid which helps sensitize TNF-α induced apoptosis and suppress human lung adenocarcinoma.
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