Corynoxine

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For Research Use Only.

Size	Price	Stock	Quantity
10 mg	$398	In stock

Category

Alkaloids

Cat.No.

NP0436

CAS

6877-32-3

Product Name

Corynoxine

Structure

Product Details

Description

Corynoxine is an enantiomer of Corynoxine B. It induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells. By inducing autophagy, it promotes the clearance of wild-type and A53T α-syn in inducible PC12 cells. It also significantly decreased locomotor activity after oral administration to mice.

Synonyms

(16E)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester

IUPAC Name

methyl (E)-2-[(3S,6'S,7'S,8'aS)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate

Molecular Weight

384.47

Molecular Formula

C22H28N2O4

Canonical SMILES

CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O

InChI

InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15+,19+,22+/m1/s1

InChIKey

DAXYUDFNWXHGBE-NRAMRBJXSA-N

Boiling Point

560.8±50.0°C (Predicted)

Melting Point

166-168°C

Purity

>98%

Density

1.239 g/cm3

Appearance

Solid

Definition

ChEBI: A natural product found in Uncaria macrophylla.

EINECS

211-708-6

Form

Powder

MDL

MFCD09953806

pKa

13.61±0.60(Predicted)

Uses

Corynoxine is an indole alkaloid extracted from Uncaria plants, and have been shown to affect locomotor response in mice . Research points to a mediation of the central dopaminergic system.

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