Corylifol A

Inquiry

For Research Use Only.

Category

Flavonoids

Cat.No.

NP1971

CAS

775351-88-7

Product Name

Corylifol A

Structure

Product Details

Description

Corylifol A is extracted from the seeds of Psoralea corylifolia L and belongs to phenolic compounds. It inhibits IL-6-induced STAT3 promoter activity in Hep3B cells wihch IC50 value is 0.81 ± 0.15 uM. It also inhibited SARA PLpro in a dose-dependent manner(IC50 value rangs between 4.2 and 38.4 μM). It has been found to be naturally occurring potent inhibitors of hCE2 with low Ki values ranging from 0.62μM to 3.89μM.

Synonyms

3-[3-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-4H-1-benzopyran-4-one;Corylinin;3'-Geranyl-4',7-dihydroxyisoflavone

IUPAC Name

3-[3-[(2E)-3,7-dimethylocta-2,6-dienyl]-4-hydroxyphenyl]-7-hydroxychromen-4-one

Molecular Weight

390.47

Molecular Formula

C25H26O4

Canonical SMILES

CC(=CCCC(=CCC1=C(C=CC(=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O)C)C

InChI

InChI=1S/C25H26O4/c1-16(2)5-4-6-17(3)7-8-19-13-18(9-12-23(19)27)22-15-29-24-14-20(26)10-11-21(24)25(22)28/h5,7,9-15,26-27H,4,6,8H2,1-3H3/b17-7+

InChIKey

ZBHUUXLHDOUMKM-REZTVBANSA-N

Boiling Point

609.3±55.0 °C | Condition: Press: 760 Torr

Purity

>98%

Density

1.191±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr

Solubility

10 mM in DMSO

Appearance

Solid powder

Application

Corylifol A inhibits IL-6-induced STAT3 promoter activity in Hep3B cells wihch IC50 value is 0.81 ± 0.15 uM. It also inhibited SARA PLpro in a dose-dependent manner(IC50 value rangs between 4.2 and 38.4 μM).

Shelf Life

2 month in rt, long time

Storage

-20°C Freezer

Form

Powder

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