Corydine

Inquiry

For Research Use Only.

Category

Alkaloids

Cat.No.

NP0298

CAS

476-69-7

Product Name

Corydine

Structure

Product Details

Description

Corydine is an alkaloid found primarily in the Corydalis genus of plants, known for its potential analgesic, antineoplastic, antimicrobial, anti-inflammatory, and neuroprotective effects. It interacts with neurotransmitter systems in the brain, making it a subject of interest for research into pain relief and neurological health.

Synonyms

4H-Dibenzo[de,g]quinolin-1-ol, 5,6,6a,7-tetrahydro-2,10,11-trimethoxy-6-methyl-, (6aS)-; (6aS)-5,6,6a,7-Tetrahydro-2,10,11-trimethoxy-6-methyl-4H-dibenzo[de,g]quinolin-1-ol; 4H-Dibenzo[de,g]quinolin-1-ol, 5,6,6a,7-tetrahydro-2,10,11-trimethoxy-6-methyl-, (S)-; 6aα-Aporphin-1-ol, 2,10,11-trimethoxy-; (+)-Corydine; (S)-(+)-Corydine; 1-Hydroxy-2,10,11-trimethoxy-6aα-aporphine; 2,10,11-Trimethoxy-6aα-aporphin-1-ol; d-Corydine; Glaucentrin; Glaucentrine; O11-Methylcorytuberine

IUPAC Name

(6aS)-2,10,11-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

Molecular Weight

341.40

Molecular Formula

C20H23NO4

Canonical SMILES

OC1=C(OC)C=C2C3=C1C(C(OC)=C(OC)C=C4)=C4C[C@]3([H])N(CC2)C

InChI

InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)19(22)18-16(12)13(21)9-11-5-6-14(23-2)20(25-4)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1

InChIKey

IDQUPXZJURZAGF-ZDUSSCGKSA-N

Boiling Point

505.7±50.0 °C at 760 mmHg

Melting Point

165-167 °C

Purity

98%

Density

1.222±0.06 g/cm3

Solubility

Soluble in Chloroform (Slightly), Methanol (Slightly, Sonicated)

Appearance

White to off-white solid

Storage

Store at 2-8 °C, under inert atmosphere

Alpha

D20 +204° (c = 1.6 in chloroform)

Form

Powder

pKa

9.68±0.20(Predicted)

Refractive Index

1.5614 (estimate)

Toxicity

LD50 subcutaneous in mouse: 115mg/kg

Uses

(+)-Corydine is an isoquinoline alkaloid from the tubers of corydalis cava and has been shown to inhibit acetylcholinesterase in a dose-dependant manner.

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