Cophylline

Inquiry

For Research Use Only.

Category

Alkaloids

Cat.No.

NP0424

CAS

142741-24-0

Product Name

Cophylline

Structure

Product Details

Description

Conophylline, also called Polyervine, is a natural alkaloid found in the leaves of Tabernaemontana divaricata, it is a bis (indole) alkaloid consisting of two pentacyclic aspidosperma skeletons, plays a key role in the regulation of cell mass proliferation, maintenance of the undifferentiated state of iPMSCs and also promotes iPMSCs differentiated into insulin-producing cells.

Synonyms

Polyervine;
[8,15'-Biaspidospermidine]-3,3'-dicarboxylicacid,2,2',3,3'-tetradehydro-6',7':7,16'-diepoxy- 6,15-dihydroxy-16,17-dimethoxy-,dimethyl ester, (5a,6b,7a,8a,12b,19a)-(5'a,6'b,7'b,12'b, 19'a)-;
2H,22H-Indolo[2'',3'':7',8']pyrrolo[1'',2'',3'':1',8'

IUPAC Name

dimethyl 14,25-diethyl-24,33-dihydroxy-31,32-dimethoxy-12,22-dioxa-1,9,18,29-tetrazadodecacyclo[23.13.1.16,9.02,23.03,21.05,19.06,17.011,13.028,36.030,35.036,39.014,40]tetraconta-3,5(19),16,20,27,30,32,34-octaene-16,27-dicarboxylate

Molecular Weight

794.9

Molecular Formula

C44H50N4O10

Canonical SMILES

CCC12CC(=C3C4(C1N(CC4)C5C(C2O)OC6=CC7=C(C=C56)C89CCN1C8C(CC(=C9N7)C(=O)OC)(C2C(C1)O2)CC)C1=CC(=C(C(=C1N3)OC)OC)O)C(=O)OC

InChI

InChI=1S/C44H50N4O10/c1-7-41-16-20(37(51)55-5)34-44(23-14-25(49)30(53-3)31(54-4)28(23)46-34)10-12-48(40(41)44)29-19-13-22-24(15-26(19)57-32(29)35(41)50)45-33-21(38(52)56-6)17-42(8-2)36-27(58-36)18-47-11-9-43(22,33)39(42)47/h13-15,27,29,32,35-36,39-40,45-46,49-50H,7-12,16-18H2,1-6H3

InChIKey

QZRIMAMDGWAHPQ-UHFFFAOYSA-N

Purity

>96%

Appearance

Yellow powder

Form

Powder

Uses

Conophylline can be used in pharmacological activity and therapeutic use of differentiation of adipose-derived stem cells into functional islet-like cells using conophlline and nicotinamide.

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