Description
This alkaloid has been isolated from a number of plants including Colchicum kesselringii, C. luteum Baker, and M. robusta Bge.
Synonyms
beta-Lumicolchicine; b-Lumi (-)-Colchicine; β-Lumicolchicine; (-)-β-Lumicolchicine; β-Lumi-(-)-colchicine; N-[(7S,7bR,10aS)-5,6,7,7b,8,10a-Hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl]acetamide
IUPAC Name
N-[(10S,12R,16S)-3,4,5,14-tetramethoxy-13-oxo-10-tetracyclo[9.5.0.02,7.012,16]hexadeca-1(11),2,4,6,14-pentaenyl]acetamide
Molecular Formula
C22H25NO6
Canonical SMILES
CC(=O)NC1CCC2=CC(=C(C(=C2C3=C1C4C3C=C(C4=O)OC)OC)OC)OC
InChI
InChI=1S/C22H25NO6/c1-10(24)23-13-7-6-11-8-15(27-3)21(28-4)22(29-5)16(11)17-12-9-14(26-2)20(25)18(12)19(13)17/h8-9,12-13,18H,6-7H2,1-5H3,(H,23,24)/t12-,13+,18-/m1/s1
InChIKey
VKPVZFOUXUQJMW-FHSNZYRGSA-N
Density
1.30±0.1 g/cm3 (20 oC 760 Torr)
Solubility
Chloroform (Slightly), Methanol (Sparingly)
Appearance
Pale Yellow Solid
Storage
Amber Vial, -20°C Freezer, Under Inert Atmosphere
Stability
Light Sensitive
Uses
An analog of Colchicine, β-lumicolchicine, does not bind tubulin or disrupt microtubules.