Colchicine

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For Research Use Only.

Size	Price	Stock	Quantity
1 g	$298	In stock

Category

Alkaloids

Cat.No.

NP0518

CAS

64-86-8

Product Name

Colchicine

Structure

Product Details

Description

Colchicine, a toxic plant-derived alkaloid extracted from plants of the genus Colchicum, inhibits microtubule polymerization (IC50 = 3.2 μM). It inhibits the growth of MCF-7 human breast carcinoma cells and has anti-inflammatory activity. Colchicine can lower body temperature, inhibit the respiratory center, enhance the effect of sympathomimetic drugs, constrict blood vessels, and raise blood pressure.

Synonyms

(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; (-)-Colchicine; Colchineos; Colchisol; Colcin; Colsaloid; Condylon; NSC 757

IUPAC Name

N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

Molecular Weight

399.44

Molecular Formula

C22H25NO6

Canonical SMILES

CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

InChI

InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChIKey

IAKHMKGGTNLKSZ-INIZCTEOSA-N

Boiling Point

726.0±60.0°C at 760 mmHg

Melting Point

150-160°C (dec.)

Purity

>98%

Density

1.32 g/cm3

Solubility

Slightly soluble in Chloroform, Methanol

Appearance

White to Yellow Solid

Storage

Tightly closed. Dry. Keep in a well-ventilated place. Light sensitive.

Form

Powder

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