Citreorosein

Anthraquinones

NP0918

481-73-2

Citreorosein

Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni
cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells, it represents a potential therapeutic approach for the treatment of inflammatory diseases.
Citreorosein attenuates degranulation and LTC 4 generation through the suppression of multiple step signaling and would be beneficial for the prevention of allergic
inflammation. Bioassay directed isolation of C. nigricans leaf extract yielded anthraquinones emodin, citreorosein, and emodic acid and a flavonoid, luteolin, they can kill mosquito larvae Anopheles gambiaea adult B. tabaci, thus the extract of C. nigricans has the potential to be used as an organic approach to manage some of the the agricultural pests.

1,3,8-Trihydroxy-6-hydroxymethylanthraquinone; 1,3,8-trihydroxy-6-(hydroxymethyl)anthracene-9,10-dione; ω-Hydroxyemodin

1,3,8-trihydroxy-6-(hydroxymethyl)anthracene-9,10-dione

286.2

C15H10O6

C1=C(C=C(C2=C1C(=O)C3=C(C2=O)C(=CC(=C3)O)O)O)CO

InChI=1S/C15H10O6/c16-5-6-1-8-12(10(18)2-6)15(21)13-9(14(8)20)3-7(17)4-11(13)19/h1-4,16-19H,5H2

YQHZABGPIPECSQ-UHFFFAOYSA-N

288 °C

>97%

1.702g/cm3

Orange powder

Anti-inflammatory

Powder