Chrysophanol

Anthraquinones

NP0901

481-74-3

Chrysophanol

Chrysophanic acid (Chrysophanol) is a natural anthraquinone with anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 µm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. Chrysophanol is a natural compound found in the roots and rhizomes of Rheum palmatum L. It can be used in cosmetics material.

1,8-dihydroxy-3-methylanthracene-9,10-dione

1,8-dihydroxy-3-methylanthracene-9,10-dione

254.24

C15H10O4

CC1=CC(=C2C(=C1)C(=O)C3=C(C2=O)C(=CC=C3)O)O

InChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3

LQGUBLBATBMXHT-UHFFFAOYSA-N

Sublimes

194-197 °C

≥ 98 %

0.92 g/cm cu at 25 °C

less than 1 mg/mL at 64 °F

Orange solid

anti-inflammatory

Powder

MFCD00001208

1 g

Stable under recommended storage conditions

3.69X10-10 mm Hg at 25 °C (est)