Description
It is produced by the strain of Streptormyces venezuelae. Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections.
Synonyms
Chloromycetin; Halomycetin; Levomicetina
IUPAC Name
2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
Molecular Formula
C11H12Cl2N2O5
Canonical SMILES
C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]
InChI
InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
InChIKey
WIIZWVCIJKGZOK-RKDXNWHRSA-N
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Appearance
White to Off-white Solid
Application
It is effective against tetracycline-resistant vibrios.
Toxicity
LD50 = 1500 mg/kg (Oral, mouse); LD50 = 2500 mg/kg (Oral, rat).