Description
It is produced by the strain of Semisynthetic third generation oral cephalosporin. Cefixime is an antibiotic useful for the treatment of a number of bacterial infections.
Synonyms
FK-027; FR-17027; CL-284635; Cefixoral; Cefspan; Cephoral; Unixime; Cefixima; Cefiximum; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)((carboxymethoxy)imino)acetyl)amino)-3-ethenyl-8-oxo-, trihydrate, (6R-(6alpha,7beta(Z)))-
IUPAC Name
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Molecular Formula
C16H15N5O7S2
Canonical SMILES
C=CC1=C(N2C(C(C2=O)NC(=O)C(=NOCC(=O)O)C3=CSC(=N3)N)SC1)C(=O)O
InChI
InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1
InChIKey
OKBVVJOGVLARMR-QSWIMTSFSA-N
Melting Point
> 170 °C (dec.)
Density
1.85±0.1 g/cm3 (Predicted)
Solubility
Slightly soluble in Water, DMSO, Methanol; Sparingly soluble in anhydrous Ethanol; Practically insoluble in Ethyl Acetate
Appearance
White to Yellowish Crystalline Powder
Application
Cefixime is useful for the treatment of a number of bacterial infections, such as in acute otitis media, respiratory tract infections, and urinary tract infections and so on. It is effective against a variety of Gram-negative bacteria, including E. coli, K. pneumoniae, and H. influenzae.
Shelf Life
2 month in rt, long time
Storage
2-8 °C under inert atmosphere