Carpachromene

Flavonoids

NP1871

57498-96-1

Carpachromene

Carpachromene is isolated from the herbs of Garcinia xanthochymus. Carpachromene shows significant α-glucosidase inhibitory activity. Carpachromene blocks protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated macrophages, thus it could be a potential anti-inflammatory agent. Carpachromene exhibits significant cytotoxicity against HepG2, PLC/PRF/5 and Raji cancer cell lines in vitro.

1. 5-hydroxy-8-(4-hydroxyphenyl)-2,2-dimethyl-pyrano[3,2-g]chromen-6-one

5-hydroxy-8-(4-hydroxyphenyl)-2,2-dimethylpyrano[3,2-g]chromen-6-one

336.34

C20H16O5

CC1(C=CC2=C(O1)C=C3C(=C2O)C(=O)C=C(O3)C4=CC=C(C=C4)O)C

InChI=1S/C20H16O5/c1-20(2)8-7-13-16(25-20)10-17-18(19(13)23)14(22)9-15(24-17)11-3-5-12(21)6-4-11/h3-10,21,23H,1-2H3

YXOATFKTEDZPFL-UHFFFAOYSA-N

Yellow powder

Yellow

Powder