Cardamonin

For Research Use Only.
Category
Chalcones
Cat.No.
NP0933
CAS
19309-14-9
Product Name
Cardamonin
Structure

Product Details

Description
Cardamonin is a naturally occuring chalcone initially isolated from the seeds of Amomum subulatum and subsequently from other zingiberous plant species. Cardamonin exhibits its antiinflammatory activity via suppression of p65NF-κB nuclear translocation and I-κBɑ phosphorylation. Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.
Synonyms
(E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one; 2',4'-dihydroxy-6'-methoxychalcone; cardamomin; cardamonin
IUPAC Name
(E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one
Molecular Weight
270.28
Molecular Formula
C16H14O4
Canonical SMILES
COC1=CC(=CC(=C1C(=O)C=CC2=CC=CC=C2)O)O
InChI
1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+
InChIKey
NYSZJNUIVUBQMM-BQYQJAHWSA-N
Boiling Point
484.5±45.0 °C at 760 Torr
Melting Point
203-205 °C
Purity
>98%
Density
1.282±0.06 g/cm3
Solubility
DMSO: ≥ 28 mg/mL
Appearance
Orange powder
Application
anti-inflammatory
Storage
Store in a cool and dry place (or refer to the Certificate of Analysis).
Form
Powder
Hazard Codes
N
HS Code
29242990
pKa
7.00±0.40(Predicted)
RIDADR
UN 3077 9 / PGIII
Risk Statements
50/53
Safety Statements
61-24/25
Stability
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 weeks.
Uses
Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos.
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