Cardamonin

Inquiry

For Research Use Only.

Category

Chalcones

Cat.No.

NP0933

CAS

19309-14-9

Product Name

Cardamonin

Structure

Product Details

Description

Cardamonin is a naturally occuring chalcone initially isolated from the seeds of Amomum subulatum and subsequently from other zingiberous plant species. Cardamonin exhibits its antiinflammatory activity via suppression of p65NF-κB nuclear translocation and I-κBɑ phosphorylation. Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.

Synonyms

(E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one; 2',4'-dihydroxy-6'-methoxychalcone; cardamomin; cardamonin

IUPAC Name

(E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

Molecular Weight

270.28

Molecular Formula

C16H14O4

Canonical SMILES

COC1=CC(=CC(=C1C(=O)C=CC2=CC=CC=C2)O)O

InChI

1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+

InChIKey

NYSZJNUIVUBQMM-BQYQJAHWSA-N

Boiling Point

484.5±45.0 ℃ at 760 Torr

Melting Point

203-205 ℃

Purity

>98%

Density

1.282±0.06 g/cm3

Solubility

DMSO: ≥ 28 mg/mL

Appearance

Orange powder

Application

anti-inflammatory

Storage

Store in a cool and dry place (or refer to the Certificate of Analysis).

Form

Powder

Hazard Codes

HS Code

29242990

pKa

7.00±0.40(Predicted)

RIDADR

UN 3077 9 / PGIII

Risk Statements

50/53

Safety Statements

61-24/25

Stability

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 weeks.

Uses

Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos.

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