Canthin-6-one

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For Research Use Only.

Size	Price	Stock	Quantity
1 mg	$439	In stock

Category

Alkaloids

Cat.No.

NP0101

CAS

479-43-6

Product Name

Canthin-6-one

Structure

Product Details

Description

Canthin-6-one, coming from the barks of Ailanthus altissima, is antiproliferative, possibly by interfering with the G2/M transition. Proapoptotic effects might result from this disturbance of the cell cycle.

Synonyms

6H-Indolo(3,2,1-de)(1,5)naphthyridin-6-one

IUPAC Name

1,6-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-3,5(16),6,8,10,12,14-heptaen-2-one

Molecular Weight

220.2

Molecular Formula

C14H8N2O

Canonical SMILES

C1=CC=C2C(=C1)C3=C4N2C(=O)C=CC4=NC=C3

InChI

InChI=1S/C14H8N2O/c17-13-6-5-11-14-10(7-8-15-11)9-3-1-2-4-12(9)16(13)14/h1-8H

InChIKey

ZERVJPYNQLONEK-UHFFFAOYSA-N

Boiling Point

346.5±34.0°C (Predicted)

Melting Point

161-161.5°C

Purity

>98%

Density

1.40±0.1 g/cm3(Predicted)

Solubility

Chloroform (Slightly), Methanol (Slightly)

Appearance

Powder

Application

Antiproliferative/antimicrobial/antiinflammatory

Storage

Refrigerator

Definition

ChEBI: An indole alkaloid that is 6H-indolo[3,2,1-de][1,5]naphthyridine substituted by an oxo group at position 6.

EINECS

200-258-5

Form

Powder

pKa

4.40±0.20(Predicted)

Uses

Canthin-6-one is used as an anticancer agent compromising cancer cells showing multi-drug resistance. Also used in the synthesis of β-carbolinium compounds as antimalarial agents.

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