Canagliflozin

Inquiry

For Research Use Only.

Size	Price	Stock	Quantity
1 g	$178	In stock

Category

Impurities

Cat.No.

NP3628

CAS

842133-18-0

Product Name

Canagliflozin

Structure

Product Details

Description

Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.

Synonyms

D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-; JNJ-24831754; TA-7284; JNJ 24831754; TA 7284; JNJ24831754; TA7284; (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol; (2S,3R,4R,5S,6R)-2-(3-((5-(4-Fluorophenyl)thien-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; 1-(β-D-Glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene; Invokana; JNJ 24831754ZAE; JNJ 28431754AAA

IUPAC Name

(2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-3,4,5-triol

Molecular Weight

444.52

Molecular Formula

C24H25FO5S

Canonical SMILES

CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F

InChI

InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22

InChIKey

XTNGUQKDFGDXSJ-ZXGKGEBGSA-N

Boiling Point

642.9±55.0°C at 760 mmHg

Melting Point

68-72°C

Purity

>98%

Density

1.364±0.06 g/cm3

Solubility

Soluble in DMSO (Slightly), Methanol (Slightly)