BUTEIN

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For Research Use Only.
Category
Chalcones
Cat.No.
NP0931
CAS
487-52-5
Product Name
BUTEIN
Structure
Structure

Product Details

Description
Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR. The use of these compounds in the treatment of breast cancer on the estrogen ground has been taken into account.
Synonyms
AC1NQY7L; AC1N-QY7L; AC1N QY7L; CCG-208298; CCG208298; CCG 208298; CS-5675; CS5675; CS-5675; NSC-652892; NSC652892; NSC 652892
IUPAC Name
(E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
Molecular Weight
272.25
Molecular Formula
C15H12O5
Canonical SMILES
C1=CC(=C(C=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O)O
InChI
InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+
InChIKey
AYMYWHCQALZEGT-ORCRQEGFSA-N
Boiling Point
560.9±50.0°C (Predicted)
Melting Point
216°C
Purity
>98%
Density
1.483±0.06 g/cm3(Predicted)
Solubility
DMSO: >50 mg/mL
Appearance
Orange powder
Application
anticancer activity; anti-inflammatory activity
Storage
2-8°C
Definition
ChEBI: A chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2', 3, 4 and 4'.
EINECS
207-659-5
Form
Powder
HS Code
29145090
MDL
MFCD00017300
pKa
7.44±0.35(Predicted)
Safety Statements
22-24/25
Uses
Butrin, isobutrin, and butein from medicinal plant butea monosperma selectively inhibit nuclear factor-κB in activated human mast cells: suppression of tumor necrosis factor-α, interleukin (IL)-6, and IL-8.
WGK Germany
3
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