BUTEIN

Inquiry

For Research Use Only.

Category

Chalcones

Cat.No.

NP0931

CAS

487-52-5

Product Name

BUTEIN

Structure

Product Details

Description

Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR. The use of these compounds in the treatment of breast cancer on the estrogen ground has been taken into account.

Synonyms

AC1NQY7L; AC1N-QY7L; AC1N QY7L; CCG-208298; CCG208298; CCG 208298; CS-5675; CS5675; CS-5675; NSC-652892; NSC652892; NSC 652892

IUPAC Name

(E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one

Molecular Weight

272.25

Molecular Formula

C15H12O5

Canonical SMILES

C1=CC(=C(C=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O)O

InChI

InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+

InChIKey

AYMYWHCQALZEGT-ORCRQEGFSA-N

Boiling Point

560.9±50.0°C (Predicted)

Melting Point

216°C

Purity

>98%

Density

1.483±0.06 g/cm3(Predicted)

Solubility

DMSO: >50 mg/mL

Appearance

Orange powder

Application

anticancer activity; anti-inflammatory activity

Storage

2-8°C

Definition

ChEBI: A chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2', 3, 4 and 4'.

EINECS

207-659-5

Form

Powder

HS Code

29145090

MDL

MFCD00017300

pKa

7.44±0.35(Predicted)

Safety Statements

22-24/25

Uses

Butrin, isobutrin, and butein from medicinal plant butea monosperma selectively inhibit nuclear factor-κB in activated human mast cells: suppression of tumor necrosis factor-α, interleukin (IL)-6, and IL-8.

WGK Germany

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