Bruceine B

Diterpenoids

NP1413

25514-29-8

Bruceine B

Bruceine B is extracted from the fruits of Brucea javanica (L.) Merr. It is a potent inhibitor of leukocyte-endothelial cell adhesion and shows anti-inflammatory activity. It displays strong antiviral activities with IC50 values of 3.42-5.66 microM and strong antitrypanosomal activities with IC50 values of 2.9-17.8nM. It also shows potent anti-malarial activities with high selective toxicities. It inhibits SMMC-7721, HL-60, MCF-7 and A-549 tumor cells significantly. It also inhibits T cell adhesion to TNF-stimulated HUVEC and neutrophil adhesion to lipopolysaccharide-stimulated HUVEC.

15β-Acetoxy-13,20-epoxy-3,11β,12α-trihydroxy-2,16-dioxopicras-3-en-21-oic acid methyl ester; (11beta,12alpha,15beta)-15-(Acetyloxy)-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxo-picras-3-en-21-oic acid methyl ester; NSC 132793

480.46

C23H28O11

CC1=C(C(=O)CC2(C1CC3C45C2C(C(C(C4C(C(=O)O3)OC(=O)C)(OC5)C(=O)OC)O)O)C)O

InChI=1S/C23H28O11/c1-8-10-5-12-22-7-32-23(20(30)31-4,17(22)15(19(29)34-12)33-9(2)24)18(28)14(27)16(22)21(10,3)6-11(25)13(8)26/h10,12,14-18,26-28H,5-7H2,1-4H3/t10-,12+,14+,15+,16+,17+,18-,21-,22+,23-/m0/s1

YDWODLQEUPYKGJ-LZFWDZGBSA-N

98.0%

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